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KMID : 0855520070200040355
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Korean Journal of Physical Anthropology
2007 Volume.20 No. 4 p.355 ~ p.362
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Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3β in the Central Nervous System of SOD1G93A Transgenic Mice
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Joo Kyeung-Min
Lee Won-Bok
Kim Kyung-Yong
Chung Yoon-Hee
Kim Sung-Su
Cha Choong-Ik
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Abstract
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In the present study, we investigated influences of glycogen synthase kinase (GSK) 3β on the development and/or progression of amyotrophic lateral sclerosis (ALS).
We used transgenic mice expressing a human Cu/Zn superoxide dismutase mutant (SOD1G93A) as an in vivo model of ALS and examined expressional changes of GSK3β immunohistochemically in the spinal cord, brain stem and cerebellum. With these experiments we demonstrate that the neurons in these regions of symptomatic SOD1G93A transgenic mice showed increased GSK3β immunoreactivities compared with wild-type SOD1 transgenic mice. In contrast to symptomatic SOD1G93A transgenic mice, few GSK3β immunoreactivity changes were detected in 8w- and 13w-old presymptomatic SOD1G93A transgenic mice.
These data suggest the possibility that GSK3 functions as a modulating factor of apoptosis-related alterations in ALS and that GSK3β exert differential functions in the development and/or progression of ALS. But the exact functional significances of these changes require further elucidation.
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KEYWORD
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Glycogen synthase kinase(GSK) 3β, Amyotrophic lateral sclerosis(ALS), SOD1G93A transgenic mice, Spinal cord, Brain stem, Cerebellum
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